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Below is a list of research articles for the Perio Protect Method. For a more indepth look, go to www.perioprotect.com/research.asp.

 

Mark S. Putt, MSD, PhD, Howard M. Proskin, PhD. Custom Tray Application of Peroxide Gel as an Adjunct to Scaling and Root Planing in the Treatment of Periodontitis: A Randomized, Controlled Three-Month Clinical Trial. The Journal of Clinical Dentistry. 2012 March(XXIII-Number 2): 48-56.

CONCLUSION: The adjunctive use over three months of 1.7% hydrogen peroxide gel, locally administered using prescription customized trays in the treatment of subjects with moderate to advanced periodontitis, demonstrated statistically significant clinical improvements in pocket depths and bleeding when compared with SRP alone.

Click here for the full text online article.

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C.M. Mitchell, D. Keller, L. Weaks, B. Sindelar. 6-Month Multi-clinic Treatment of Periodontal Disease Using Topical Oxidizing Agents - abstract link.

OBJECTIVES: Determine whether use of PerioProtect Method ® (PPM) in combination with scaling and root-planing (SRP) over 6-months would result in improvements in outcome measures in patients with periodontal disease (PD).

METHODS: 44 patients with mild to severe PD were treated by 4 dentists in separate clinics. Dentists were specially trained in PerioProtect® system. Subject distribution was: Dentist-1, 11 patients (7 male; ages 5213); Dentist-2, 15 patients (3 male; ages 5715); Dentist-3, 15 patients (4 male; ages 5514); Dentist-4, 3 patients (1 male; ages 4920). All patients underwent baseline evaluation for PPD per tooth (6 sites per tooth) and BoP (dichotomous per site). Prior to treatment all patients received instruction on supra-gingival care and the use of PPM. Each Dentist administered a specific combination of PPM and SRP treatment: Group A (7 male; 9 female; age 5313) received whole mouth SRP prior to use of PPM and Group B (7 male; 21 female; age 5514) received PPM first followed by site-specific SRP. Changes in PPD and BoP for all patients were reassessed after a 6 month period.

RESULTS: Baseline averages indicated no significant difference in PPD between Groups A and B (p>0.232); however there was significantly more BoP in patients in Group A at baseline than Group B (p=0.003). At 6 months, PPD values for 0-5mm pockets for all patients significantly improved from baseline (p<0.001) and differences between Dentists were not significant (p>0.360). At 6 months all patients had significantly decreased BoP (p<0.01) with no significant differences noted between Dentists (p>0.556) or between treatment Groups (p>0.361).

CONCLUSIONS: An appropriately trained general Dentist can effectively administer PPM. PPM is effective for improving PPDs and BoP within 6 months in mild to moderate cases of periodontal disease regardless of whether full mouth SRP is followed by PPM or PPM is followed by site-specific SRP.

Click here for the research poster presentation.

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T Dunlap, DC Keller, M Marshall, JW Costerton, C Schaudinn, BJ Sindelar, and JR Cotton. Subgingival Delivery of Oral Debriding Agents: A Proof of Concept. The Journal of Clinical Dentistry. 2011 November(XXII-Number 5):149-158.

The prescription Perio Tray® effectively placed medication in the gingival sulcus. Mathematical modeling indicated Perio Tray® placement of hydrogen peroxide gel in periodontal pockets with depths up to 9 mm over 15 minutes treatment time was theoretically possible.

Click here for the full text online article.

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Keller DC. How to Manage Oral Biofilm. Dental Products Report. 2010 July(7):54-55..

Radiographs and charts from this case study indicate that medication placed into periodontal pockets with the prescription Perio Tray® helped decrease bleeding, and reduce pocket depths for a patient who had struggled with gum disease for years. The patient had had two previous rounds of surgical procedures, including bone recontouring, and was recommended to have all lower anterior teeth extracted. In an effort to save his teeth, he opted for treatment with the Perio Protect Method® which included delivery of medication with prescription Perio Trays®. After treatment, bleeding and pocket depths decreased and additional bone support is also evident. With the gain in bone support, the lower anterior teeth did not need to be extracted.

Click here for the full text online.

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Schaudinn C, Gorur A, Sedghizadeh P, Costerton J, and Keller D. Manipulation of the microbial ecology of the periodontal pocket. World Dental 2010 Feb-March: 14-18.

The data suggest that the biofilm potential is an accurate indicator of the microbiological health of the sulcus, and further suggest that the efficient delivery of antibacterial oxidants via the Perio Protect system, which uses an oxidative chemical strategy before the physical removal of the biofilms by scaling and root planing (SRP), is an effective treatment for periodontitis.

Click here for the full text online article.

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Schaudinn C, Gorur A, Keller D, Sedghizadeh PP, Costerton JW. Center for Biofilms, School of Dentistry, University of Southern California, Los Angeles, CA90089, USA. Periodontitis: An archetypical biofilm disease. J Am Dent Assoc. 2009 Aug;140(8):978-86.

BACKGROUND: Periodontitis is a classic example of biofilm-mediated diseases.

METHODS: The authors reviewed selected publications in English-language peer-reviewed journals with respect to microbial biofilms, focusing on representative works that provided a historical to a contemporary perspective on periodontal oral biofilms in the larger context of biofilm microbiology.

RESULTS: Developments in advanced microscopy and molecular microbiology have allowed scientists to examine and characterize microbial biofilm-mediated diseases, such as periodontitis, more accurately than in the past.

CONCLUSIONS: Periodontitis, like other biofilm infections, is refractory to antibiotic agents and host defenses because the causative microbes live in complex communities that persist despite challenges that range from targeted antibiotic agents to phagocytosis.

CLINICAL IMPLICATIONS: The regular delivery of nontargeted antibiofilm agents may be an effective strategy for treating biofilms, especially if these agents include oxidative agents that dissolve the biofilm matrix.

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Preliminary Data on Periodontal Disease Treatment Using Topical Oxidizing Agents - abstract link

1151 Preliminary Data on Periodontal Disease Treatment Using Topical Oxidizing Agents DC Keller DMD1, LT Nguyen, BS2, LR Jobe, BS2, and BJ Sindelar PT, PhD2 1Perio Protect LLC, Saint Louis, MO; 2School of Physical Therapy, Ohio University, Athens, OH

Click here for the research poster presentation.

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SEM Results of Periopathogenic Control with the Perio Protect Method - abstract link

1186 SEM Results of Periopathogenic Control with the Perio Protect Method D.C. KELLER 1, B. COSTERTON 2, C. SCHAUDINN 2, and G.S. KELLER 3, 1Perio Protect, Saint Louis, MO, USA, 2USC School of Dentistry, Los Angeles, CA, USA, 3Keller Professional Group P.C, St. Louis, MO, USA

Above are Before treatment (left) and after 17 days of Perio Protect treatment (right), both scales represent 5 μm.

Click here for the research poster presentation.

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C-reactive protein changes during Perio Protect treatment of periodontal disease -abstract link

1195 C-reactive protein changes during Perio Protect treatment of periodontal disease C. STEELE, Keller Professional Group PC, St. Louis, MO, USA, B.J. SINDELAR, Ohio University, Athens, USA, and D.C. KELLER, Perio Protect, Saint Louis, MO, USA

Click here for the research poster presentation.

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Initial Study of the Perio Protect TM Treatment for Periodontal Disease - abstract link

1164 Initial Study of the Perio Protect TM Treatment for Periodontal Disease L.E. WENTZ 1, A.M. BLAKE 1, D.C. KELLER 2, and B.J. SINDELAR 2, 1Ohio University, Athens, USA, 2Keller Professional Group PC, St. Louis, MO, USA

Click here for the research poster presentation.

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